Antineoplastic

Antineoplastic Agents

Antineoplastic Immunoconjugates and Immunotoxins

PROLOGUE This paper discusses the scientific rationale, synthesis, therapeutic utility and clinical limitations of cancer chemotherapy with antineoplastic drugs or toxins covalently linked to monoclonal antibodies directed against tumor cell antigens. Chemical issues that must be considered when designing an effective antineoplastic immunoconjugate or immunotoxin (including purity, functional g...

Antibacterial activities of antineoplastic agents.

Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Only 5-fluorouracil, mitomycin, and etoposide demonstrated inhibitory effects at achievable plasma concentrations, while the remaining drugs lacked appreciable antibacterial activities.

Regional Administration of Antineoplastic Drugs

Regional antineoplastic drug delivery is not a new concept. Following the initial recognition that cytotoxic alkylating agents could cause shrinkage of tumor masses and a reduction in the quantity of malignant ascites in patients with advanced ovarian cancer, investigators in the 1950s instilled the drugs directly into the peritoneal cavity in an effort to treat the malignancy (1). Similarly, i...

Pharmacological characterization of antineoplastic alkylphosphocholines

The Unit of Toxicology and Chemotherapy originated in 1993 from the former Division of Carcinogenesis and Chemotherapy. The objective of this unit is to better understand mechanisms of toxicity and carcinogenesis of drugs and chemicals and to develop improved methods for diagnosis and treatment of cancer. In this context the mechanism of action as well as the spectrum of anticancer and anti-pro...